O4 COMPLEX

Every member of the Remediq product range contains O₄ Complex, a proprietary plant-based ingredient developed by our experts to provide cellular-level protection.

O₄ Complex is a unique antioxidant formula containing bioactive plant compounds, including the flavonoids quercetin, luteolin, and fisetin, as well as the alkaloid piperine. These carefully selected ingredients support multiple aspects of the body's function while helping protect cells against oxidative stress.

Bibliography:

Fan X, Fan Z, Yang Z, Huang T, Tong Y, Yang D, Mao X, Yang M. Flavonoids—Natural Gifts to Promote Health and Longevity. International Journal of Molecular Sciences. 2022;23(4):2176. doi:10.3390/ijms23042176. PMID: 35216290; PMCID: PMC8879655.https://pmc.ncbi.nlm.nih.gov/articles/PMC8879655/
Frenț OD, Stefan L, Morgovan CM, Duteanu N, Dejeu IL, Marian E, Vicaș L, Manole F. A systematic review: quercetin - secondary metabolite of the flavonol class, with multiple health benefits and low bioavailability. Int J Mol Sci. 2024 Nov 11;25(22):12091. doi:10.3390/ijms252212091. PMID:39596162; PMCID:PMC11594109. https://pmc.ncbi.nlm.nih.gov/articles/PMC11594109/
Seelinger G, Merfort I, Schempp CM. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 2008;74(14):1667-1677. doi:10.1055/s-0028-1088314. PMID: 18937165. https://pubmed.ncbi.nlm.nih.gov/18937165/
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WHAT MAKES THE O₄ COMPLEX UNIQUE?

Cellular Antioxidant Protection

The flavonoids in the formula possess powerful antioxidant properties that may help neutralize free radicals and reduce the harmful effects of oxidative stress.¹

Support During Inflammatory Processes

Quercetin and luteolin may help support a healthy inflammatory response and protect cells from oxidative damage.²˒³

Mental Clarity and Nervous System Support

Fisetin is one of the most extensively researched flavonoids today. Through its antioxidant and anti-inflammatory properties, it may help support healthy nervous system function and promote cognitive performance.⁴

Piperine for Enhanced Flavonoid Activity

Flavonoids often exhibit limited bioavailability in their natural form.⁵ In addition to its own beneficial physiological properties, piperine may help enhance the absorption and utilization of the other ingredients in the O₄ Complex, thereby supporting their overall effectiveness.⁶

Maximum Bioavailability with Liposomal Technology

A key feature of the formula is its use of advanced liposomal technology. Liposomes are tiny spherical structures with a membrane similar to that of human cells. They help protect active ingredients from degradation in the digestive system while enhancing their absorption and facilitating more efficient delivery into cells. As a result, the body is able to utilize a greater proportion of these valuable compounds.⁷˒⁸˒⁹˒¹⁰

O₄ COMPLEX INGREDIENTS

Quercetin

Quercetin is one of the best-known plant-derived flavonoids and is naturally found in significant amounts in onions, apples, berries, green tea, and citrus fruits.
Quercetin possesses powerful antioxidant properties that may help neutralize free radicals, thereby contributing to the reduction of oxidative stress and the protection of cells. It may also help support the regulation of the body's inflammatory responses by influencing the production of certain pro-inflammatory compounds. Through these mechanisms, quercetin may contribute to maintaining the body's natural balance and overall well-being.¹¹˒¹²

Luteolin

Luteolin is a plant-derived flavonoid naturally found in celery, parsley, chamomile, green peppers, and carrots. Known for its antioxidant properties, luteolin may help neutralize free radicals and protect cells from oxidative stress–related damage.¹³ Research suggests that luteolin may also influence certain inflammatory pathways and help modulate the production of inflammatory mediators, thereby supporting the body's natural balance and contributing to cellular protection.³

Fisetin

Fisetin is a plant-derived flavonoid naturally found in strawberries, apples, grapes, onions, and cucumbers.
Research suggests that fisetin may help protect nerve cells against oxidative stress and inflammatory processes.⁴ Due to its antioxidant and anti-inflammatory properties, it may support the healthy functioning of the nervous system.¹⁴ Studies also indicate that fisetin may have a positive influence on memory, learning processes, and cognitive function, while potentially helping to mitigate age-related changes in neurological health.⁴

Piperin

Piperine is a naturally occurring bioactive compound (alkaloid) found in black pepper (Piper nigrum) and long pepper (Piper longum).
Piperine has been associated with a wide range of beneficial physiological properties. Research suggests that its antioxidant and anti-inflammatory effects may help support cellular protection and contribute to maintaining the body’s natural balance.¹⁵ It may also support immune function, cardiovascular health, and the healthy functioning of the liver and nervous system.¹⁶ Additional studies have highlighted its potential anti-allergic, antidiabetic, antimicrobial, and healthy-aging properties.¹⁶
Studies indicate that piperine and piperine-containing compounds may enhance the bioavailability of certain nutrients, plant-derived active ingredients, and selected medications by improving their absorption into the bloodstream.⁶ This property makes piperine a valuable component in formulations designed to optimize the utilization of bioactive compounds.